Molecular classification of endometrial cancers: The way forward

The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies.

BACKGROUND Understanding and identifying molecular biology and genetics of endometrial cancer are central to the development of novel therapies. This article reviews the molecular basis for genesis of endometrial cancer with regard to pathogenesis, classification, and implications for targeted therapies. METHODS Genes and cellular pathways that may have an important role in endometrial cancer...

health scope in iran: the way forward

The Way Forward Is the Way Back

“T viewer should see the object as I saw it, but with a lot of room for his own interpretation....The painting is like a very clear mirror which is barely visible but unmistakably there,” reflects Spanish painter Antonio López García (b. 1936) (1). “I am nostalgic for an art of our times in which a greater number of people can participate” (1). Part of a contemporary movement rooted in the trad...

Genetics of Endometrial Cancers

Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological and clinical types. The most frequently altered gene in estrogen-dependent endometrioid endometrial carcinoma tumors is PTEN. Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent ...

Thalidomide--the way forward.